Recent Advances in the Hydrogel-Based Biomolecule Delivery System for Cartilage Tissue Engineering

Many investigations have been conducted to explore new therapeutic approaches for cartilage tissue regeneration owing the limited repair ability of cartilage. Delivery biomolecules is a promising strategy enhancing regeneration. However, direct delivery in vivo generally leads rapid loss product or possibility spreading nontarget sites, which may weaken their effectiveness and impair translation these strategies into clinical practice. Recently, engineering using controlled systems considered overcome weaknesses by regulating spatiotemporal distribution biomolecules. Hydrogels are carriers development biomolecule because they highly tunable can be fabricated encapsulate bioactive control release. Moreover, favorable biocompatibility integrate host facilitate use wide variety situations. This review summarizes recent design hydrogels as